White paper - Proteomics at scale: Current approaches and emerging technologies

The landscape of proteomics technologies has traditionally been defined by trade offs between coverage - the ability to detect many proteins - and detail - the ability to confidently measure the abundance of every detected protein as well as the ability to quantify proteoforms. In this white paper, we explore the pros and cons of emerging and traditional proteomics technologies in terms of coverage and detail. Furthermore, we discuss how the Nautilus Proteome Analysis Platform is designed to employ a novel proteomic analysis method called Iterative Mapping to overcome tradeoffs between coverage and detail and deliver a complete proteomics solution.